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For US Healthcare Professionals

RESULTS IN PRIMARY PROGRESSIVE MS (PPMS)

Proven effective

for primary progressive MS

DISABILITY PROGRESSION
BRAIN LESIONS
OCREVUS ZUNOVO CLINICAL STUDY

OCREVUS is the only approved treatment for PPMS

Find out why OCREVUS may be the right choice for treating your primary progressive multiple sclerosis (PPMS). See results and understand how OCREVUS was evaluated in a clinical trial.

Clinical study by the numbers

People included in the study:

  • 732 people (488 taking OCREVUS, 244 taking placebo)
  • 18–55 years of age
  • Average time since people experienced the start of symptoms was about 7 years
  • Had not previously received MS disease-modifying treatment (89%) and those who had (11%)

Why this is important:

  • Studied in a large group of people
  • Studied in a variety of people who have MS
  • Study included people who had not been taking a treatment and those who had

DISABILITY PROGRESSION

OCREVUS was proven to delay disability progression of PPMS

*OCREVUS was studied against a placebo. A placebo is a substance or treatment that has no active medicine. It is common for treatment to be compared with a placebo when there are no existing approved treatments to compare it with. Disability progression was measured using a tool called the Expanded Disability Status Scale (EDSS). Disability progression was confirmed 3 months after the initial neurological worsening.
†Disability progression was also confirmed after 6 months.

What is disability progression and why does it matter?

Disability progression is the increase in physical disability that happens over time for people with MS. How and when it happens is different for everyone. It can also vary in severity.

Some people may find they struggle with walking or remembering their “to-do” list. Others may experience tingling or numbness or blurred vision. While some may dismiss or overlook these symptoms, they may be a sign of disability progression—and over time, decreased mobility.

How is disability progression measured in clinical studies?

Disability progression is measured using a tool called the Expanded Disability Status Scale (EDSS). It assesses your functionality or changes to function in the areas listed below. OCREVUS was not proven to individually reduce each of these measured endpoints.

Icon of an eye

Visual functions - problems with sight or involuntary eye movements

Icon of a person with a cane hunched over in pain

Muscle weakness or difficulty moving limbs and walking

Icon of a brain with a question mark

Cerebral functions - problems with thinking or memory

Icon of a shaking hand

Tremor or loss of coordination

Icon of a hand with the fingertips highlighted

Numbness or loss of sensations

Icon of a stomach with an exclamation point

Bowel or bladder function

Icon of a head with highlighted neck

Problems with speech or swallowing

Select Important Safety Information

Infusion reactions are a common side effect of OCREVUS, which can be serious and may require you to be hospitalized. You will be monitored during your infusion and for at least 1 hour after each infusion of OCREVUS for signs and symptoms of an infusion reaction. Tell your healthcare professional or nurse if you get any reactions. Please visit Safety & Side Effects for more information.

BRAIN LESIONS

OCREVUS saw superior results in lesion volume

OCREVUS reduced the volume of T2 hyperintense lesions, while T2 lesion volume increased in people taking placebo.

The average change in volume of T2 lesions was -0.39 cm3 for OCREVUS compared with 0.79 cm3 for placebo.‡

‡OCREVUS was evaluated in a study including 732 people who were treated with OCREVUS or placebo for at least 120 weeks.

Lesions in MS:

  • Lesion volume is the total amount of lesion area, including both old and new lesions, and is measured using magnetic resonance
  • T2 hyperintense lesions may reflect new inflammation or older, chronic lesions that are a sign of scarring from previous MS activity

Why is this important?

While you may not see them, MS can cause lesions to develop in the central nervous system (CNS). Over time, if these lesions progress, some of them may lead to a variety of symptoms that may be more noticeable. Reducing the development of new lesions is an important step in slowing MS progression.

OCREVUS ZUNOVO® Clinical Study

The similarity of OCREVUS ZUNOVO subcutaneous injections to OCREVUS infusions was confirmed in a separate study.

This study measured the amount of medicine in the bloodstream, which is commonly done to check that the injection works like infusion. The results of the study showed there were no clinically significant differences between OCREVUS ZUNOVO and OCREVUS.

Now that I’ve seen the results, what’s next?

After reviewing the results and safety, having an honest conversation with your doctor is the next step. Our Doctor Discussion Guide can help shape the conversation around your symptoms, lifestyle, and goals so that you might find a treatment that is right for you.

Click below to either create a personalized list of questions to ask at your appointment or view a guide with commonly asked questions.

Personalize My Guide
View Common Questions

What is the treatment experience like with OCREVUS ZUNOVO or OCREVUS?

Whether you’re getting OCREVUS ZUNOVO injections or OCREVUS infusions, both treatment options are just 2 times a year.§ Your treatment may be given at an infusion center, your doctor’s office, or at home depending on what you and your doctor decide is right for you. Find out more about what to expect at your treatment appointment.

Learn About Treatment Options

§First treatment will be split into 2, for a total of 3 treatments the first year.

Important Safety Information & Indications

What are OCREVUS and OCREVUS ZUNOVO?

OCREVUS and OCREVUS ZUNOVO are prescription medicines used to treat:

  • Relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults
  • Primary progressive MS, in adults.

It is not known if OCREVUS and OCREVUS ZUNOVO are safe and effective in children.

Who should not receive OCREVUS or OCREVUS ZUNOVO?

Do not receive OCREVUS or OCREVUS ZUNOVO if you:

  • have an active hepatitis B virus (HBV) infection.
  • have had a life-threatening administration reaction to ocrelizumab.
  • have had a life-threatening allergic reaction to ocrelizumab, hyaluronidase, or any of the ingredients of OCREVUS ZUNOVO. Tell your healthcare provider if you have had an allergic reaction to OCREVUS or OCREVUS ZUNOVO or any of their ingredients in the past.

What is the most important information I should know about OCREVUS and OCREVUS ZUNOVO?

OCREVUS and OCREVUS ZUNOVO can cause serious side effects, including:

  • Infusion reactions (OCREVUS): Infusion reactions are a common side effect of OCREVUS, which can be serious and may require you to be hospitalized. You will be monitored during your infusion and for at least 1 hour after each infusion of OCREVUS for signs and symptoms of an infusion reaction.
  • Injection reactions (OCREVUS ZUNOVO): Injection reactions are a common side effect of OCREVUS ZUNOVO, which can be serious and may require you to be hospitalized. You will be monitored for signs and symptoms of an injection reaction when you receive OCREVUS ZUNOVO. This will happen during all injections for at least 1 hour after your first injection, and for at least 15 minutes after all injections following the first injection.

Tell your healthcare provider or nurse if you get any of these symptoms:

  • itchy skin
  • trouble breathing
  • nausea
  • shortness of breath
  • rash
  • throat irritation or pain
  • headache
  • fatigue
  • hives
  • feeling faint
  • swelling of the throat
  • fast heartbeat
  • tiredness
  • fever
  • dizziness
  • coughing or wheezing
  • redness on your face (flushing)

Additionally, for OCREVUS ZUNOVO:

  • injection site pain
  • swelling
  • redness

These infusion and injection reactions can happen during or up to 24 hours after administration. It is important that you call your healthcare provider right away if you get any of the signs or symptoms listed above after each infusion or injection.

  • Infection:
    • Infections are a common side effect. OCREVUS and OCREVUS ZUNOVO increase your risk of getting upper respiratory tract infections, lower respiratory tract infections, skin infections, and herpes infections. Serious infections can happen with OCREVUS and OCREVUS ZUNOVO, which can be life-threatening or cause death. Tell your healthcare provider if you have an infection or have any of the following signs of infection including fever, chills, or a cough that does not go away, or painful urination. Signs of herpes infection include: cold sores, shingles, genital sores, skin rash, pain, and itching. Signs of more serious herpes infection include: changes in vision, eye redness or eye pain, severe or persistent headache, stiff neck, and confusion. Signs of infection can happen during treatment or after you have received your last dose of OCREVUS or OCREVUS ZUNOVO. Tell your healthcare provider right away if you have an infection. Your healthcare provider should delay your treatment with OCREVUS or OCREVUS ZUNOVO until your infection is gone.
      • Hepatitis B virus (HBV) reactivation: Before starting treatment with ocrelizumab, your healthcare provider will do blood tests to check for hepatitis B viral infection. If you have ever had hepatitis B virus infection, the hepatitis B virus may become active again during or after treatment with OCREVUS or OCREVUS ZUNOVO. Hepatitis B virus becoming active again (called reactivation) may cause serious liver problems including liver failure or death. Your healthcare provider will monitor you if you are at risk for hepatitis B virus reactivation during treatment and after you stop receiving OCREVUS or OCREVUS ZUNOVO.
      • Weakened immune system: OCREVUS or OCREVUS ZUNOVO taken before or after other medicines that weaken the immune system could increase your risk of getting infections.
  • Progressive Multifocal Leukoencephalopathy (PML): PML is a rare brain infection that usually leads to death or severe disability and has been reported with ocrelizumab. Symptoms of PML get worse over days to weeks. It is important that you call your healthcare provider right away if you have any new or worsening neurologic signs or symptoms that have lasted several days, including problems with:
    • thinking
    • eyesight
    • strength
    • balance
    • weakness on 1 side of your body
    • using your arms or legs
  • Decreased immunoglobulins: OCREVUS and OCREVUS ZUNOVO may cause a decrease in some types of immunoglobulins. Your healthcare provider will do blood tests to check your blood immunoglobulin levels.

Before receiving OCREVUS or OCREVUS ZUNOVO, tell your healthcare provider about all of your medical conditions, including if you:

  • have or think you have an infection. See “What is the most important information I should know about OCREVUS and OCREVUS ZUNOVO?”
  • have ever taken, take, or plan to take medicines that affect your immune system, or other treatments for MS. These medicines could increase your risk of getting an infection.
  • have ever had hepatitis B or are a carrier of the hepatitis B virus.
  • have a history of inflammatory bowel disease or colitis.
  • have had a recent vaccination or are scheduled to receive any vaccinations.
    • You should receive any required ‘live’ or ‘live-attenuated’ vaccines at least 4 weeks before you start treatment with OCREVUS or OCREVUS ZUNOVO. You should not receive ‘live’ or ‘live-attenuated’ vaccines while you are being treated with OCREVUS or OCREVUS ZUNOVO and until your healthcare provider tells you that your immune system is no longer weakened.
    • When possible, you should receive any ‘non-live’ vaccines at least 2 weeks before you start treatment with OCREVUS or OCREVUS ZUNOVO. If you would like to receive any non-live (inactivated) vaccines, including the seasonal flu vaccine, while you are being treated with OCREVUS or OCREVUS ZUNOVO, talk to your healthcare provider.
    • If you have a baby and you received OCREVUS or OCREVUS ZUNOVO during your pregnancy, it is important to tell your baby’s healthcare provider about receiving OCREVUS or OCREVUS ZUNOVO so they can decide when your baby should be vaccinated.
  • are pregnant, think that you might be pregnant, or plan to become pregnant. It is not known if OCREVUS and OCREVUS ZUNOVO will harm your unborn baby. You should use birth control (contraception) during treatment with OCREVUS and OCREVUS ZUNOVO and for 6 months after your last dose of OCREVUS or OCREVUS ZUNOVO. Talk with your healthcare provider about what birth control method is right for you during this time. Tell your healthcare provider if you become pregnant while receiving OCREVUS or OCREVUS ZUNOVO.
  • are breastfeeding or plan to breastfeed. It is not known if OCREVUS and OCREVUS ZUNOVO pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take OCREVUS or OCREVUS ZUNOVO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of OCREVUS and OCREVUS ZUNOVO?

OCREVUS and OCREVUS ZUNOVO may cause serious side effects, including:

  • Risk of cancers (malignancies) including breast cancer: Follow your healthcare provider’s instructions about standard screening guidelines for breast cancer.
  • Inflammation of the colon, or colitis: Tell your healthcare provider if you have any symptoms of colitis, such as:
    • Diarrhea (loose stools) or more frequent bowel movements than usual
    • Stools that are black, tarry, sticky or have blood or mucus
    • Severe stomach-area (abdomen) pain or tenderness

The most common side effects of OCREVUS ZUNOVO include:

  • Injection reactions
  • Respiratory tract infections
  • Skin infections

These are not all the possible side effects of OCREVUS and OCREVUS ZUNOVO.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Genentech at (888) 835-2555.

For more information, go to www.OCREVUS.com or call 1-844-627-3887.

Please see additional Important Safety Information throughout and click here for full Prescribing Information and Medication Guide for OCREVUS.

Please see additional Important Safety Information throughout and click here for full Prescribing Information and Medication Guide for OCREVUS ZUNOVO.

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