RESULTS IN PRIMARY PROGRESSIVE MS (PPMS)
RESULTS IN PRIMARY PROGRESSIVE MS (PPMS)
Find out why OCREVUS may be the right choice for treating your primary progressive multiple sclerosis (PPMS). See results and understand how OCREVUS was evaluated in a clinical trial.
*OCREVUS was studied against a placebo. A placebo is a substance or treatment that has no active medicine. It is common for treatment to be compared with a placebo when there are no existing approved treatments to compare it with. Disability progression was measured using a tool called the Expanded Disability Status Scale (EDSS). Disability progression was confirmed 3 months after the initial neurological worsening.
†Disability progression was also confirmed after 6 months.
Disability progression is the increase in physical disability that happens over time for people with MS. How and when it happens is different for everyone. It can also vary in severity.
Some people may find they struggle with walking or remembering their “to-do” list. Others may experience tingling or numbness or blurred vision. While some may dismiss or overlook these symptoms, they may be a sign of disability progression—and over time, decreased mobility.
Disability progression is measured using a tool called the Expanded Disability Status Scale (EDSS). It assesses your functionality or changes to function in the areas listed below. OCREVUS was not proven to individually reduce each of these measured endpoints.
OCREVUS increases your risk of getting upper respiratory tract infections, lower respiratory tract infections, skin infections, and herpes infections. Infections are a common side effect, which can be serious. Tell your healthcare provider if you have an infection or have any of the following signs of infection including fever, chills, or a cough that does not go away. Signs of herpes include cold sores, shingles, genital sores, skin rash, pain, and itching. Signs of more serious herpes infection include: changes in vision, eye redness or eye pain, severe or persistent headache, stiff neck, and confusion. Signs of infection can happen during treatment or after you have received your last dose of OCREVUS. Tell your healthcare provider right away if you have an infection. Your healthcare provider should delay your treatment with OCREVUS until your infection is gone. Please visit Safety & Side Effects for more information.
OCREVUS reduced the volume of T2 hyperintense lesions, while T2 lesion volume increased in people taking placebo.
The average change in volume of T2 lesions was -0.39 cm3 for OCREVUS compared with 0.79 cm3 for placebo.‡
‡OCREVUS was evaluated in a study including 732 people who were treated with OCREVUS or placebo for at least 120 weeks.
Why is this important?
While you may not see them, MS can cause lesions to develop in the central nervous system (CNS). Over time, if these lesions progress, some of them may lead to a variety of symptoms that may be more noticeable. Reducing the development of new lesions is an important step in slowing MS progression.
OCREVUS Prescribing Information. Genentech, Inc. 2016.
OCREVUS Prescribing Information. Genentech, Inc. 2016.
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